Bernadette, That necklace sounds lovely. May I ask what size the Akoya are? The reason I ask is I struggle with the knots when I alternate very small and medium to large beads. I end up either having knots looking to large for the small beads or knots the larger beads can slide over.
I also have converted to all PowerPro. I use 10b, 15lb, 20lb, and 30lb depending on the size of the pearls. I have used 4+ strands before of the 10lb and agree the knots are very nice and fit well against the pearls.