I have used the smallest hand held Dremel with a Beadalon drill bit to enlarge existing holes on Pearls, but haven't tried to drill undrilled pearls. I have no problem holding the pearl between my finger and thumb, but the hand holding the drill does get a lot of vibration. You need a dish of water handy to cool the drill bit and the pearl periodically. If I were drilling a large number of Pearls, I would look into a standing stationary type drill. I once drilled an Akoya Pearl that cracked in half and I was amazed to see how thin the nacre was that popped off of it, and the bead inside looked like what dental crowns are made of. Since then I use only Freshwater Pearls, the best quality I can find.