When I was new to cultured pearls, I kept thinking that some strands of un-nucleated freshwater pearls were natural because of the slight variations in shape, which akoyas don't have. That variation is still something I love about Chinese freshwater pearls because it does make them look more natural than pearls with nuclei.
And I have since learned that once you really know what natural pearls look like, it is easier to recognize that a freshwater pearl does not look the same as a natural one. The typical shapes of the off-round pearls and the luster in natural pearls are different than the example above.